postoperative cognitive dysfunction
Conditions
Interventions
two groups:Different depth by Anesthesia Using Propofol
Sponsors
The Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Written informed consent provided by legal guardians or patients; 2. Male or female patients between 50 and 70 years of age; 3. ASA physical status I or II patients; 4. Education Years of patients are more than 6 years; 5. The operation going to be received is the first operation in patients life (a second operation was a risk factor for early post- operative); 6. The operation going to be received is presenting for a moderate surgery in general surgery department such as subtotal gastrectomy, radical surgery for gastric cancer, splenectomy operation and so on.
Exclusion criteria
Exclusion criteria: 1. The patient has the history of neurologic or mental disease; 2. The patient has renal dysfunction, serum creatinine >177 mmol/L; 3. The patient is going to receive surgery of thyroid, intracranial procedure, joint replacement, major fracture; 4. The patient is unable to complete neuropsychologic testing; 5. The patient has vision dysfunction or auditory dysfunction; 6. The operation going to be received is a laparoscopic surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative cognitive dysfunction;risk factors of postoperative cognitive dysfunction;relationship between the depth of anesthesia and stress response, genetic factor; | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety index; | — |
Countries
China
Contacts
Public ContactYangwen Ou
The Third Xiangya Hospital of Central South University
Outcome results
None listed