Impair Glucose Tolerant
Conditions
Interventions
treatment group:Metformin cloridrate
Control:Education of diet and movement
Sponsors
the First Affiliated Hospital of NanChang University
Eligibility
Sex/Gender
All
Age
30 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Understanding and willing to participate in the test before the signing of the subjects informed consent; 2. Aged 30 to 64 years; 3. According to the WHO standard, the subjects should be diagnosed as IGT; 4. No taking any medicine affecting blood glucose; 5. BMI 20 to 35 kg/m2; 6. HbA1c 6.0 to 6.4%; 7. The subjects were able to and willing to self monitoring of blood glucose.
Exclusion criteria
Exclusion criteria: 1. Hepatic and renal function damage, 2.5 times larger than the upper limit of the normal value of ALT; 1.5 times larger than the upper limit of the normal value of serum creatinine; 2. A history of drug abuse and alcohol dependence history in the past 5 years; 3. Treatment with systemic corticosteroids within 2 months before the 3 screening; 4. The clinical significance of the activity, the (past 12 months) of cardiovascular disease subjects (including a history of myocardial infarction (MI), ECG was shown to arrhythmia or conduction block, unstable angina, or decompensated heart failure (New York Heart Association [NYHA] class III and class IV); 5. The known hypersensitivity to test the pharmaceutical or related products; 6.The pregnancy, breastfeeding or interested in pregnancy, or judgment for not using adequate contraception (adequate contraception is the IUD, oral contraceptives and impede measures); 7. Any other decision by the investigator obvious or combined diseases: such as endocrine, heart, nerve, tumor and other diseases, other pancreatic disease or, painful neuropathy; 8.Blood pressure can not be controled after treatment / without treatment of severe hypertension (defined as systolic pressure = 180mmHg and / or DBP = 100mmHg); 9. He or she had participated in other clinical study of drugs or devices in the past 3 months; 10. Mental disorders, unwilling or language barriers, difficulty understanding, cooperation and the use of blood glucose meter maker.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| esRAGE; | — |
Secondary
| Measure | Time frame |
|---|---|
| hsCRP;TNF-a; | — |
Countries
China
Contacts
Public ContactXU Jixiong
the First Affiliated Hospital of NanChang University
Outcome results
None listed