Helicobacter pylori infection and duodenal ulcer
Conditions
Interventions
Esomeprazole magnesium:Treatment with concomitant therapy (including esomeprazole magnesium), 10 days
Omeprazole magnesium:Treatment with concomitant therapy (including omeprazole magnesium), 10 days
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 years and 70 years (including 18 and 70 years); 2. Hp positive patients with Duodenal ulcer (without complications); 3. Duodenal ulcer stging: A1 and A2; 4. Rapid urease test (?2+) and/or positive in 13C breath test; 5. Regular eradication therapy was never received.
Exclusion criteria
Exclusion criteria: 1. Treatment with steroids or non-steroidal anti-inflammatory drugs, proton pump inhibitors H2 receptor antagonists and antibiotics within 4 weeks of entry; 2. Duodenal ulcer with staging H,S and comlications (active hemorrhage, perforation and obstruction); 3. Previous gastric surgery; 4. Pregnancy or lactation; 5. Concomitant severe disease; 6. Allergic to medicine in this trial; 7. Participated in other clinical trial within 3 month; 8. Unable to cooperate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ulcer healing Rate;Prevalence of CYP2C19 gene polymorphisms;Prevalence of IL-1B gene polymorphism; | — |
Countries
China
Contacts
Public ContactNong-Hua Lu
The First Affiliated Hospital of Nanchang University
Outcome results
None listed