Acute Myeloid Leukemia
Conditions
Interventions
haplo-SCT:undergo haplo-SCT
ASCT:undergo ASCT
Sponsors
Department of Hematology, the First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 year and more; 2. Diagnosed as AML (except acute promyelocytic leukemia M3) for the first time; 3. Minimal Residual Disease (MRD) test can be achieved (molecular biology first if applicable, and/or cytogenetics and/or immunophenotyping); 4. Presence of an available haplo-mismatch related donor.
Exclusion criteria
Exclusion criteria: 1. Contra-indications of chemotherapy or hematopoietic stem cell transplantation; 2. Presence of an available identical sibling donor or a 10/10 HLA loci-matched unrelated donor; 3. Participating in other clinical trials concerning the prophylaxis of disease recurrence after ASCT; 4. No effective contraception; 5. Pregnant or lactating females; 6. Other causes which are not suitable for the trial in investigator's consideration.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Leukemia Free Survival;Non-relapse Mortarlity;Incidence of Engraftment;Quality of Life; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall Survival;Relapse Incidence; | — |
Countries
China
Contacts
Public ContactWU Depei
Department of Hematology, the First Affiliated Hospital of Soochow University
Outcome results
None listed