NSCLC in stage IV with oligo metastases
Conditions
Interventions
A:adjuvant chemotherapy and radiotherapy
B:neoadjuvant chemotherapy + adjuvant chemotherapy and radiotherapy
Sponsors
Cancer Hospital of Sichuan province
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. voluntary and signed written informed consent; 2. aged 18 to 75 years, sex not limited; 3. pathology or cytology in the diagnosis of NSCLC (squamous cell carcinoma, adenocarcinoma and large cell carcinoma); 4. primary tumors can measure; 5. distant organ metastases number = 5, and metastasis can be measured; 6. Karnofsky score >70; 7. survival is expected to exceed 3 months; 8. reproductive age women should ensure that before entering the study period contraception; 9. HB =100 g/L, WBC =4 × 10^9/L, platelet = 100 × 10^9/L; 10. liver function: the upper limit of normal value of ALT, AST< (ULN) 1.5 times, total bilirubin <1.5 x ULN; 11. renal function: serum creatinine <1.5 x ULN; 12. patients have good compliance to treatment and follow-up of acceptance.
Exclusion criteria
Exclusion criteria: 1. Do not meet the inclusion criteria for patients with pathologic type and primary site. 2. to pemetrexed, cisplatin, docetaxel and contrast medium allergy. 3. distant organ metastases number > 5. 4. the primary tumor, lymph node and metastases has underwent surgical operation (biopsy except). 5. the primary tumor, lymph node and metastases had radiotherapy. 6. had molecular targeted therapy. 7. had received chemotherapy or immunotherapy. 8. suffered from other malignant tumors. 9. in January received other drug test subjects. 10. pregnant or lactating women and treatment observation period rejected contraception in female. 11. There is serious allergic or idiosyncratic. 12. History, serious pulmonary heart disease. 13. refused or not signed the informed consent to participate in trials. 14. abuse drugs or alcohol addicts. 15. personality or psychiatric disorders, no civil capacity or with limited civil capacity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| tumor size; | — |
Countries
China
Contacts
Public ContactLi Tao
Cancer Hospital of Sichuan province
Outcome results
None listed