non-small cell lung cancer
Conditions
Interventions
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. aged between 18 and 80 years; 2. clinically diagnosed as primary non-small cell lung cancer (stage IA-IIIA) and scheduled to undergo radical surgery; 3. agreed to receive patient-controlled analgesia after surgery.
Exclusion criteria
Exclusion criteria: 1. Distant metastasis, malignant tumor in other organs or chemo-/radio- or other anti-cancer therapy before surgery; 2. comorbid with autoimmune diseases, or glucocorticoid/immunosuppressant therapy within 1 year; 3. previous history of schizophrenia, epilepsy or Parkinson disease, or unable to complete preoperative assessment due to severe dementia, language barrier, or end-stage disease, or other disorders related to the development of tumors, i.e. depression or other psychological disorders; 4. history of anesthesia (including general anesthesia and epidural anesthesia) and/or surgery within 1 year; 5. contraindications to epidural anesthesia, including spinal deformity, coagulation dysfunction, local infection, history of spinal trauma/surgery; 6. severe hepatic insufficiency (Child-Pugh classification C), kidney insufficiency (serum creatinine >442 umol/L or receiving renal replacement therapy), or American Society of Anesthesiologist (ASA) physical status classification >=IV; 7. allergic to any medication (including local anesthetic and opioids) during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| recurrence-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of intensive care unit (ICU) admission after surgery;Incidence of postoperative complications during hospital stay;Length of chest tube drainage after surgery;Length of stay in hospital after surgery;All-cause in-hospital mortality after surgery;Activety engagement among 1-year survivors;Cancer-specific survival;Overall survival; | — |
Countries
China
Contacts
Public ContactWang Dongxin
Peking University First Hospital
Outcome results
None listed