A randomized controlled trial of atorvastatin therapy in intensive care patients with sepsis

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-14004134

Enrollment

Unknown

Registered

2014-01-14

Start date

2014-02-28

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis

Interventions

1:atorvastatin 20mg/day

2:placebo 20mg/day

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Aged between 18 to 90 years old; 2. there is a clear source of infection, infection or highly suspected exist, in line with the 2001 international conference on sepsis definition of sepsis in the diagnosis of the new standard.

Exclusion criteria

Exclusion criteria: 1. poor general condition; 2. pregnant or lactating women; 3. dying patients can't tolerate statins, not by oral use of statins; 4. poor ALT > 5 times in patients with normal liver function, or abnormal muscle enzymes CK > 10 times the normal value; 5. in ICU patients taking a statin within 72 hours before.

Design outcomes

Primary

Measure	Time frame
ICU mortality;14 day mortality;PCT;	—

Secondary

Measure	Time frame
erythrocyte sedimentation rate;CK;ALT;CRP;	—

Countries

China

Contacts

Public ContactTong-Wen Sun

Department of Integrated ICU, the First Affiliated Hospital of Zhengzhou University

suntongwen@163.com+86 13838516916

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026