Postoperative cognitive dysfunction
Conditions
Interventions
A:At 10 min before induction of anesthesia, In Group A butorphanol 2 mg were dropped into the nasal cavity
B:At 10 min before induction of anesthesia, in Group B butorphanol 2 mg were injected into vein slowly
C:At 10 min before induction of anesthesia,in Group C fentanyl 0.1 mg were dropped into the nasal cavity
D:At 10 min before induction of anesthesia, in Group D the patients were injected with equal volume of physiological saline.
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
Male
Age
65 Years to 77 Years
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiology (ASA) I or II; 2. Mini-Mental State Examination (MMSE) score of > 23; 3. greater than six years of education; 4. no history of neurological diseases or hyperthyroidism; 5. normal liver and kidney function; 6. no impairment of vision and hearing; and 7. no administration of sedative, antidepressant or analgesic drugs; 8. All patients aged 65-77 years males, body weight 888- 111Kg, BMI 28-35kg/m2, apnea hypopnea index (AHI)ranged from 21 to 42 times/h.
Exclusion criteria
Exclusion criteria: 1. The mini mental state examination (MMSE) score<23 points; 2.the junior middle school the following cultural degree; 3. the impairment of renal function (creatinine177 umol/L) or active liver disease; 4. the central nervous system or mental illness; 5. and taking tranquilizers, antidepressants or a history of alcoholism; 6. influence the visual disorder serious AC.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score;BCS score;The scores of Mini-Mental State Examination (MMSE);The incidence of postoperative cognitive dysfunction(POCD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Amount of sulfentanyl in the operation;Amount of propofol in the operation;Amount of postoperative fentanyl; | — |
Countries
China
Contacts
Public ContactDefeng Sun
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed