Nasopharyngeal carcinoma
Conditions
Interventions
Study group:paregoric for mild pain
control group:paregoric for moderate level of pain
Sponsors
Affiliated Cancer Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Histological confirmed nasopharyngeal carcinoma; 2. Without historic chronic pain, no depend on analgesic drugs, no historic opioids intaken; 3. Plan to receive radical radiation therapy, newly to radiation for head and neck; 4. Aged older or equal to 18 years old; 5. Could understand and cooperate to accomplish pain evaluation and observation scales; 6. Sufficient liver and kidney function: ALT or AST less than 2.5*ULN, serum creatinine less than 1.5*ULN; 7. Without other serious critical organ dysfunction, such as heart or lung dysfunction; 8. PS score less than 2 (ECOG); 9. Voluntary to participate and sign informed consent document; 10. Obey the rules of trail; could be followed-up on time.
Exclusion criteria
Exclusion criteria: 1. Excluded by inclusion criteria; 2. Known or suspected allergy to NSAID or opioid medicine; 3. Unable to complete the follow-up; 4. Severe uncontrollable infections of medical disorders; 5. Major organ including heart, lung, kidney, or liver dysfunction; 6. With pathophysiological factors affecting drug absorption, distribution, metabolism or excretion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numeric rating scale;BMI Body Mass Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemoglobin;albumin;quality of lfe score;overall survival;medical outcomes study sleep scale; | — |
Countries
China
Contacts
Public ContactChen Dong-ping
Outcome results
None listed