A Clinical Study of Topiramate's Efficacy and Safety to Treat Post-Thoracotomy Pain

A Clinical Study of Topiramate's Efficacy and Safety to Treat Chronic Post-Thoracotomy Pain: A Randomized Controlled Trail

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-13005005

Enrollment

Unknown

Registered

2013-05-29

Start date

2014-07-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-Thoracotomy Pain

Interventions

A:Topiramate (25mg/piece)

B:Topiramate (25mg/piece)

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Patients with Post-Thoracotomy Pain around the incision or related area; 2. Aged 18 to 70 years old; 3. 24 hours after surgery, VAS scores more than 2; 4. Be voluntary and signed a written informed consent.

Exclusion criteria

Exclusion criteria: 1. Neuralgia caused by herpes zoster and thalamic lesions; 2. Epileptic or patients can not stop taking antiepileptic drugs or anti-neuralgia drugs; 3. Patients with chronic disease of heart, liver, kidney function damage.The liver function damage ALT more than 1.5 times upper limit of normal, renal function damage, BUN, Cr more than upper limit of normal; 4. Patients with acute or chronic heart failure or unstable angina pectoris may affect the observation of drug efficacy; 5. Pregnant or will be pregnant women and nursing mothers.

Design outcomes

Primary

Measure	Time frame
VAS score of patients;Nerve pain remission time;The Total Duration of Post-Thoracotomy Pain;The Incidence of Nerve Pain In Per 4 Weeks;	—

Countries

China

Contacts

Public ContactLi Li

lielee@fmmu.edu.cn+86 13709115155

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026