Chronic kidney disease combined with Chronic Hepatitis B infection
Conditions
Interventions
Telbivudine group:Telbivudine treatment
entecavir group:entecavir
Sponsors
Nephrology Department, the First Affiliated Hospital, Third Military Medical University
Eligibility
Sex/Gender
All
Age
16 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Males or females aged 16-70 years; 2. Nephrotic syndrome or primary glomerulonephritis combined with Hepatitis B virus infection; HBsAg positive; regardless of ALT, HBV-DNA status; 3. Nephrotic syndrome or primary glomerulonephritis combined with Hepatitis B virus infection Require a long course of Corticosteroids immunosuppression; 4. Serum creatinine less than 3mg/ml (265umol/L) or eGFR>30ml/min; 5. Have the ability to understand the requirements of the study, provide written informed consent (including consent for the use and disclosure of research-related health information), and comply with the study protocol procedures (including required study visits); participate in the study after the purpose and nature of the investigation has been clearly explained to them.
Exclusion criteria
Exclusion criteria: 1. Patients who has the severe heart, lung and hematopoietic system diseases; 2. Patients with cancer or other malignant diseases; 3. Pregnant or nursing; 4. Psychiosis, acrasia and unable to express himself explicitly; 5. Decompensated cirrhosis; 6. Serum creatinine more than 3mg/ml (265µmol/L) or eGFR<30ml/min; 7. Persons who are participating in other clinical trials; or Persons, in the opinion of investigator, are unsuitable to participate in the clinical trial for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| vital sign;24h urinary protein;Hemoglobin (HGB);Red blood cells (RBC);white blood cells (WBC);Platelets (PLC);Neutrophils;Aspartate aminotransferase (AST);Alanine aminotransferase (ALT);Serum albumin (ALBm);Blood urea nitrogen (BUN);Serum creatinine (SCr);Serum uric acid (UA);Glucose (GLU);Triglycerides;Total cholesterol;estimated GFR;Lactate dehydrogenase (LDH);a-hydroxybutyrate dehydrogenase (a-HBDH);Creatine kinase (CK);Creatine kinase (CK-MB) activity;Hepatitis B surface antigen (HBsAg);Hepatitis B surface antibody (HBsAb);Hepatitis B e antigen (HBeAg);Hepatitis B e antibody (HBeAb);Hepatitis B core antibody (HBcAb);Hepatitis B core antibody IgM;HBV DNA quantification;HBV P region sequencing;Liver ultrasound;Renal ultrasoun; | — |
Countries
China
Contacts
Public ContactZhao Hongwen
the First Affiliated Hospital, Third Military Medical University(Southwest Hospital)
Outcome results
None listed