Helicobacter pylori infection
Conditions
Interventions
Standard Quadruple Therapy:Hide susceptibility results, treatment for Clarithromycin–Amoxycillin-Containing Quadruple Therapy
Individualized Triple Therapy:Treatment for Clarithromycin–Amoxycillin-Containing Triple Therapy by culture with antimicrobial susceptibility
Individualized Quadruple Therapy:Treatment for Clarithromycin–Amoxycillin-Containing Triple Therapy by culture with antimicrobial susceptibility
Sponsors
Wenzhou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. aged 18~70 years old, Male or female, untreated patients; 2. symptoms of abdominal pain, bloating, acid reflux, belching, nausea, vomiting, heartburn, chest pain, vomiting, melena, etc; 3. unused antibiotics, bismuth, H2 receptor antagonists or PPI by Nearly 4 weeks; 4. (13)C-labelled urea breath test positive; 5. Agreed to Helicobacter pylori culture and sensitivity test taken by endoscopy gastric biopsy specimens, and the result of culture was positive; 6. Agreed to Helicobacter pylori eradication therapy and cooperate with the eradication efficacy follow-up survey.
Exclusion criteria
Exclusion criteria: 1. Severe heart, liver, kidney dysfunction; 2. Pregnant or lactating women; 3. Complications of bleeding, perforation, pyloric obstruction, cancer; 4. Esophageal,gastrointestinal surgery history; 5. Patients can not properly express their complaints,such as psychosis, severe neurosis; 6. Taking NSIAD or alcohol abusers; 7. Allergic to penicillin or either drugs of the 6 antibiotic tested by susceptibility testing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rates;Compliance rate of Cultivation and eradication;The result of (13)C-labelled urea breath test; | — |
Secondary
| Measure | Time frame |
|---|---|
| The rate of culture positive result; | — |
Countries
China
Contacts
Public ContactJie Pan
Wenzhou Central Hospital
Outcome results
None listed