liver failure
Conditions
Interventions
treatment group:ELAD treatment
control group:standard treatment
Sponsors
Beijing Youan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 16~65 years old (16 years old and 65 years old included), all genders, ability to afford standard diagnosis and treatment cost; 2. Acute, sub-acute, chronic on acute (chronically severe hepatitis) liver dysfunction and failure caused by various reasons, such as viruses, alcohol, drug-induced, inborn metabolism etc.; 3. TBil>=5×ULN or TBil daily increase more than 1mg/dL (17.1umol/L); 4. PTA 20% to 50% or INR 1.6 to 4.0 or PT 5 seconds to 20 seconds; 5. Without hepatic encephalopathy or less than grade II (grade II included); 6. without or small to medium amount ascites; 7. Patient or his/her statutory agent is able to understand and sign informed consent, communicate and cooperate with researchers to execute the study.
Exclusion criteria
Exclusion criteria: Primary hepatic carcinoma or metastatic liver cancer. 1. Occurrence of decompensation of liver cirrhosis within one year (including one of the following items PTA2×ULN, bleeding, hepatic encephalopathy, ascites); 2. Slow progression of liver failure with liver cirrhosis; 3. Serious infection without control, such as sepsis, uncontrolled pneumonia (no improvement of X ray after proper antibiotic therapy); uncontrolled abdominal infection (peritonitis symptom or ascites WBC>0.1×10^9/L after antibiotic therapy ) etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total bilirubin; | — |
Countries
China
Contacts
Public ContactZhongping Duan
Beijing Youan Hospital, Capital Medical University
Outcome results
None listed