Cognitive Dysfunction
Conditions
Interventions
A:patients received continuous intravenous infusion of the nicardipine 3 ug/kg/min
B:patients received continuous intravenous infusion of the nicardipine 3 ug/kg/min and esmolol 30ug/kg/min
C:patients received continuous intravenous infusion of the nitroglycerin 3 ug/kg/min
D:patients received continuous intravenous infusion of the nitroglycerin nicardipine 3 ug/k and esmolol 30ug/kg/min
E:an equal volume of normal saline
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
75 Years to 86 Years
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiology (ASA) II or III; 2. Mini-Mental State Examination (MMSE) score of > 23; 3. greater than six years of education; 4. no history of neurological diseases or hyperthyroidism; 5. normal liver and kidney function; 6. no impairment of vision and hearing; and 7. no administration of sedative, antidepressant or analgesic drugs.
Exclusion criteria
Exclusion criteria: 1. The mini mental state examination (MMSE) score 177 umol/L) or active liver disease; 4. the central nervous system or mental illness; 5. and taking tranquilizers, antidepressants or a history of alcoholism; 6. influence the visual disorder serious AC.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure (MAP);heart rate (HR);rate pressure product (RPP, the product of HR and systolic pressure);central venous pressure (CVP);blood oxygen saturation (SpO2);cardiac output (CO);stroke volume (SV);Mini-Mental State Examination (MMSE) scor; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bispectral index (BIS); | — |
Countries
China
Contacts
Public ContactDefeng Sun
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed