Major Depressive Disorder
Conditions
Interventions
1:Bilateral temporal and propofol
2:Bilateral temporal and etomidate
3:The right temporal and propofol
4:The right temporal and etomidate
5:Bilateral frontal and propofol
6:Bilateral frontal and etomidate
7:Control
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. All the participants aged over 18 years (when informed consent was got), male or female; 2. Meet ICD-10 diagnostic criteria for depression; 3. Scored 18 or above on the HAM-D Scale which included 17 items; 4.CGI-severity score = 4; 5. All subjects provided written informed consent..
Exclusion criteria
Exclusion criteria: 1. Any depressive disorders not due to major depressive disorder; 2. Meet other diagnosis criteria in DSM-IV-TR Axis I; 3. With a history of acute or chronic renal failure, liver cirrhosis or active hepatopathy; 4. With clinically significant abnormal results of laboratory test, which are considered to have impact on treatment efficacy and the safety of participants; 5. With a history of severe or unstable physical disease including nervous system disease and myocardial infarction; 6. Undergoing alcoholism or alcohol (or substance) abuse during 30 days or 6 months before the trial; 7. With no response to previous ECT treatment; 8. Received transcranial magnetic stimulation treatment in the last 6 months; 9. Allergic to propofol, etomidate and succinylcholine chloride; 10. During pregnancy or lactation; 11. With a history of stroke in the last month; 12. Enrolled in any other clinical trial 30 days prior to the baseline.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale(HAMD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton anxiety scale(HAMA);CGI-SI; | — |
Countries
China
Contacts
Public ContactXu Yifeng
Outcome results
None listed