Myopia
Conditions
Interventions
Group 1:0.05% atropine both eyes once daily
Group 2:0.025% atropine both eyes once daily
Group 3:0.01% atropine both eyes once daily
Group 4:0.9% normal saline (placebo) both eyes once daily (to be switched to Group 1 after one year)
Sponsors
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong
Eligibility
Sex/Gender
All
Age
4 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Aged 4 to 12 years; 2. Myopia : SE -1 to -10 D; 3. Astigmatism: 0.5 D for both eye in one year; 6. Informed parental consent.
Exclusion criteria
Exclusion criteria: 1. Ophthalmic diseases other than refractive errors; 2. Previous use of treatment of atropine; 3. Allergy or intolerance to atropine; 4. Inability to attend regular follow up assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in spherical equivalent refraction (cycloplegic refraction);Change in axial length; | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety variables: Self-reported visual function, best corrected visual acuity, pupil size, intraocular pressure, ocular and systemic symptoms, ocular signs, heart rate and blood pressure; | — |
Countries
China
Contacts
Public ContactProf. Yam Cheuk Sing Jason
The Chinese University of Hong Kong
Outcome results
None listed