allergic rhinitis
Conditions
Interventions
allergic treatment group:Budisonide nasal spray and nasal irrigation
allergic control group:Placebo spray and nasal irrigation
Sponsors
Nanjing Jinling Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. adults age 18~65; 2. gender not limited; 3. the diagnosis of allergic rhinitis (the Chinese medical association, guide to diagnosis and treatment of allergic rhinitis 2009); 4. no history of asthma symptoms (wheezing, short of breath, chest tightness, cough) or diagnosis of asthma; 5. no immune and nasal surgery treatment in recent six months; 6. no oral, suction, injected hormone therapy among recent one month; 7. in recent one month, no respiratory tract infection, no abnormal anatomy of the nasal cavity, nasal polyps, nasal septum deviation, etc.); 8. no using theophylline and leukotriene antagonists now; 9. there is no history of smoking or in one year, and smoking < 7 bags/year; 10. the subjects must voluntarily participate in the study, and comply with the requirements of the study, understand and comply with the corresponding examination; 11. comply with the drug dosage and follow-up plan.
Exclusion criteria
Exclusion criteria: 1. with COPD, interstitial pneumonia, such as the other types of chronic respiratory system disease been diagnosed; 2. concomitant other system serious disease (e.g., cardiovascular, metabolism, immunity, neural, urinary and blood, etc.); 3. temperature more than 37.5 degree C, or abnormal blood sample (white blood cell count >10*10^9/L or <4*10^9/L); 4. history of drug abuse, alcohol abuse or anesthesia or with a history of mental illness and against personality, motivation, suspicious, or other emotional or mental issues that may affect participation in the study of knowledge effectiveness; 5. pregnancy, lactation women; 6. participating in clinical trial projects or other drugs in process, can't cooperate with related inspection or for other reasons can't collaborators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eosinophil in nasal lavage;Eosinophil in induced sputum;FeNO;branchial provocation test;Histamine nasal provocation test;Eosinophil count in blood;Total IgE in serum;Total IgE in serum; | — |
Countries
China
Contacts
Public ContactWang Qiuping
Nanjing Jinling Hospital
Outcome results
None listed