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A randomized double-blind controlled study of repetitive transcranial magnetic stimulation for the treatment of cognitive impairment such as working memory in schizophrenia

A randomized double-blind controlled study of repetitive transcranial magnetic stimulation for the treatment of cognitive impairment such as working memory in schizophrenia

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-TRC-13004017
Enrollment
Unknown
Registered
2013-04-24
Start date
2013-03-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

schizophrenia

Interventions

A:20Hz rTMS
B:Sham repetitive transcranial magnetic stimulation

Sponsors

Shanghai Mental Health Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 49 Years

Inclusion criteria

Inclusion criteria: 1. patients to be diaginsed according to DSM-IV for paranoid schizophrenia; 2. Aged 20 to 49 years old; 3. Duration of 2~10 years; 4. the disease situation is stable, the fluctuation of PANSS total score <=10% in last 1 month, and have accepted the current drugs for more than 8 weeks; 5. Patients, their families and doctors are agreed that the disease situation is stable and maintainthe current drug treatmentdrug in next month; 6. Signed an informed consent.

Exclusion criteria

Exclusion criteria: 1. patients to be diaginsed according to DSM-IV for substance abused,development delayed; 2. suffering from serious physical disease and can not accept the treatment; 3. rTMS contraindications: intracranial metal substance, with heart pacemakers and cochlear implants, intracranial pressure; 4. the disease situation is not stable, the fluctuation of PANSS total score >10% in last 1 month, PANSS total score >60; 5. difficult to maintain the current drug treatment for at least 1 month; 6. undergoing ECT or MECT in last 3 months.

Design outcomes

Primary

MeasureTime frame
working memory;

Secondary

MeasureTime frame
gamma band oscillation;

Countries

China

Contacts

Public ContactLiu Dengtang

Shanghai Mental Health Center

erliu110@126.com+86 13671973730

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026