Shanghai Municipal Health Bureau
Conditions
Interventions
DN-CKD1:Fundamental intervention (behavioral interventions, glycemic control, lipid control, blood pressure control)+Vasarltan 80mg Qd P.O.+Yi Shen Gu Jing granules or placebo
DN-CKD2~3:Fundamental intervention (behavioral interventions, glycemic control, lipid control, blood pressure control)+Vasarltan 80mg Qd P.O.+Yi Shen Xie Zhuo granules or placebo
Sponsors
Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Comply with the diagnostic criteria of diabetic nephropathy; 2. Aged 18 to 70 years old; 3. eGFR> 30ml/min/1.73m2; 4. Sign the inform consent.
Exclusion criteria
Exclusion criteria: 1. Previous history of non-diabetic nephropathy; 2. Nephritis Urine (abnormal red blood cells in urine); 3. Severe renal failure eGFR evaluated as the stage of CKD4-5; 4. Unilateral or bilateral renal artery stenosis; 5. Poorly controlled blood pressure, SBP> 160mmHg, or DBP> 100mmHg patients; 6. Myocardial infarction, heart failure or unstable angina pectoris; 7. History of stroke; 8. Liver damage, ALT or AST> 2-fold; 9. Pregnant or lactating; 10. Mental disease; 11. Cancer patients; 12. Allergic to the test drugs or ingredients of the T.C.M. granules;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of endpoint events:Dialysis, doublin;UMA;24-hour urinary protein excretion;Serum creatinine;eGF; | — |
Secondary
| Measure | Time frame |
|---|---|
| BMI;Waist / hip;Blood pressure;TCM syndrome score;Serum Uric acid;Fasting plasma glucose;Glycated hemoglobin; | — |
Countries
China
Contacts
Public ContactWang Yi
Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed