The effect of mannitol on intraoperative brain relaxation in patients with supratentorial tumor surgery: a randomized, double blind, parallel controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-13003984

Enrollment

Unknown

Registered

2013-12-16

Start date

2017-01-01

Completion date

Unknown

Last updated

2018-07-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

supratentorial brain tumor

Interventions

Group A:20% mannitol 0.7g/kg

Group B:20% mannitol 1.0g/kg

Group C:20% mannitol 1.4g/kg

Group D:200ml 0.9% saline

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: The patients who will receive elective supratentorial tumor resection in Beijing Tiantan Hospital, Capital Medical University and write the inform consent will be enrolled in the study. Inclusion criteria include. Inclusion criteria: preoperative brain imaging (CT or MRI) indicating a midline shift age between 18 and 60 years.

Exclusion criteria

Exclusion criteria: ASA physical status is IV and V grade, Glassgar Coma Scale (GCS)150mEq.L-1), heart failure (EF<20%), renal insufficiency (creatinine clearance <30ml/kg), previous history of coronary heart disease.

Design outcomes

Primary

Measure	Time frame
brain relaxation;outcome;	—

Secondary

Measure	Time frame
heamodynamic parameters;dura tension;surgical exposure;requirement of additional treatment;	—

Countries

China

Contacts

Public ContactHan Ruquan

Beijing Tiantan Hospital, Capital Medical University

ruquan.han@gmail.com+86 010-67096660

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026