Periodontal intrabony defect
Conditions
Interventions
two-flap test group:Bio-Oss+Bio-Gide
single-flap test group:Bio-Oss
Sponsors
Peking University School of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients with advanced periodontal disease, in general good health, presenting with at least one isolated deep, interdental intrabony defect, after completion of initial therapy and between 18 and 65 years old are considered eligible for this study; 2. Patients give informed written informed consent and are with optimal compliance; 3. Defect anatomy. Defects are located in incisors, premolars and the first molars. Presence of one tooth with probing depth (PD) and clinical attachment loss (CAL) >/=5mm associated with interdental intrabony defect depth of >/=3mm. Keratinized gingivae is enough to cover defects and grafts. Distance between bottom of the defect and apex is no less than 3mm; 4. Patients with good oral hygiene, presenting with full-mouth plaque scores (FMPS) </=20% and full-mouth bleeding scores (FMBS) </=25%.
Exclusion criteria
Exclusion criteria: 1. Poor oral hygiene; 2. Pregnant or lactating mothers; 3. Patients have oral cancer or HIV infection; 4. Tooth accepted regenerative therapy; 5. Teeth treated by regenerative therapy, with mobility greater than grade II and furcation involvement (class II and class III), with clinical signs of untreated acute infection at surgical site, apical pathology, root fracture and severe root irregularities are excluded; 6. Smokers (>10 cigarettes per day); 7. Patients who treated for other reasons in one month; 8. Patients have leukoplakia and erythema; 9. Patients allergy to the regenerative materials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical attachment level (CAL);liner bone growt; | — |
Secondary
| Measure | Time frame |
|---|---|
| wound healing index;clinical probe depth;gingival recession;Bone probe level;volume of intrabony defect accessed by CBCT;Bone filling percentage;post-operative pain(VAS); | — |
Countries
China
Contacts
Public ContactOuyang Xiangying
Peking University School of Stomatology
Outcome results
None listed