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Efficacy of daily low-dose sildenafil for treating interstitial cystitis: results of randomized, double-blind, placebo-controlled trial

Efficacy of daily low-dose sildenafil for treating interstitial cystitis: results of randomized, double-blind, placebo-controlled trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-TRC-13003938
Enrollment
Unknown
Registered
2013-05-17
Start date
2009-06-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

interstitial cystitis

Interventions

group A:oral sildenafil
group B:oral placebo

Sponsors

The First Af?liated Hospital of Wenzhou Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 55 Years

Inclusion criteria

Inclusion criteria: All patients underwent the following diagnostic tests: positive modified potassium sensitivity test [17], cystoscopic findings of over 10 glomerulations and non-ulcer lesion in every visual field after hydrodistention (pressure: 80-100 cmH2O, duration: 2 min) under sedation or spinal anesthesia at the discretion of the clinician.

Exclusion criteria

Exclusion criteria: Patients with diabetes mellitus, mental disorder, hypertension, hypohepatia, renal insufficiency or received any treatment for IC/PBS with 3 months were excluded. Patients observed for 1 month to eliminate interference of hydrodistention. Those still having therapeutic response to hydrodistention after 1 month were also excluded.

Design outcomes

Primary

MeasureTime frame
urodynamic indices;interstitial cystitis symptom indices(ICSI);interstitial cystitis problem indices (ICPI);micturition diar;

Countries

China

Contacts

Public ContactHongde Chen

The First Affiliated Hospital of Wenzhou Medical College

85404206@qq.com+86 13857732266

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026