Generalized aggressive periodontitis
Conditions
Interventions
Group 1:Local application of PERIOCLINE immediately after full-mouth mechanical treatment
Group 2:Local application of PERIOCLINE 3 months after full-mouth mechanical treatment
Group 3:Systemic antimicrobials combined with full-mouth mechanical treatment
Sponsors
Periodontic Dept., Peking University School of Stomatology
Eligibility
Sex/Gender
All
Age
16 Years to 43 Years
Inclusion criteria
Inclusion criteria: 1. GAgP (according to the criteria of the 1999 international classification (Armitage 1999); 2. aged between 16 and 35 when first diagnosed with aggressive periodontal disease; 3. at least 20 teeth present; 4. good general health.
Exclusion criteria
Exclusion criteria: 1. suffered from any other systemic diseases (cardiovascular,pulmonary, liver, cerebral, diseases or diabetes); 2. pregnant or lactating females, or females of childbearing age not using a standard accepted method of birth control; 3. received antibiotic treatment in the previous 3 months; 4. received a course of periodontal treatment within the last 6 months; 5. required antibiotic pre-medication for the performance of periodontal examination and treatment; 6. allergic to minocycline, penicillin or metronidazole; 7. smoking; 8. not able to provide consent to participate in the study, or they do not accept the proposed treatment plan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| probing pocket depth (PPD);clinical attachment loss (CAL);Subgingival plaque microbiological outcome; | — |
Secondary
| Measure | Time frame |
|---|---|
| gingival recession;Full-mouth plaque score;Full-mouth bleeding score;blood routine test;blood glucose;blood lipid;IL-1beta;TNF-alpha; | — |
Countries
China
Contacts
Public ContactXiangying Ouyang
Periodontic Dept., Peking University School of Stomatology
Outcome results
None listed