patent ductus arteriosus in preterm infants
Conditions
Interventions
paracetamol:Oral paracetamol
ibuprofen:Oral ibuprofen
Sponsors
The First Hospital of Jilin University
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1. Birth weight <1500g; 2. postnatal age within 14 days; 3. Continuous positive airway pressure with FiO2 more than 25%; 4. Echocardiographic criteria for PDA included an increased left atrial diameter compared with the aortic root (left-atrium- to-aortic-root ratio higher than 1.4), OR visualization of the ductus (more than 1.5 mm), AND evidence of left-to-right blood flow through the open duct.
Exclusion criteria
Exclusion criteria: 1. Congenital heart disease which required PDA to maintain blood flow; 2. hocardiographic evidence of right-to-left blood flow through the open duct; 3. life-threatening infection; 4. recent (within the previous 24 h) intraventricular hemorrhage, grade 3-4; 5. urine output =133 umol/L; 7. platelet count of <=50*10^9/L; 8. hyperbilirubinemia requiring exchange transfusion; 9. bleeding tendency(defined by the presence of blood in endotracheal aspirate, gastric aspirate, stools or urines, and/or by oozing from puncture sites); 10. active necrotizing enterocolitis (NEC) and/or intestinal perforation; 11. liver disfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of ductal closure; | — |
Secondary
| Measure | Time frame |
|---|---|
| side effect; | — |
Countries
China
Contacts
Public ContactWu Hui
Department of Neonatology, The First Hospital of Jilin University
Outcome results
None listed