Aplastic anemia
Conditions
Interventions
1:CSA 3mg/kg/d, for three years
2:CSA 5mg/kg/d, for three years
Sponsors
General Hospital of Tianjin Medical University
Eligibility
Sex/Gender
All
Age
14 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) aged 14-70 years confirmed by first treated acquired AA patients; (2) in unconditional for HLA sibling donor hematopoietic stem cell transplantation; (3) economic ability accept ATG + CsA standard immunosuppressive therapy; (4) the blood biochemical indexes: ALT and AST is normal, normal serum bilirubin level, urea nitrogen, creatinine, normal electrolyte normal or after treatment to normal; (5) subject to the consent and have signed the CSA in the treatment of informed consent.
Exclusion criteria
Exclusion criteria: (1) active visceral bleeding; (2) Severe infection, after active treatment can't control; (3) abnormal cardiac function evaluation; (4) during pregnancy and lactation women; (5) childbearing age women not to take effective contraceptive measures; (6) researchers think unsuitable to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting blood concentration of CSA;Blood concentration of CSA of 2 hours after taking the drug;Consumption of CSA per kilogram per day;The frequency of taking drug per day;The cycles of taking the drug at the time of detecting concentration of CSA;Species of CSA;Age;Sex;Liver and kidney function;Treatment effect;Whether still need infusion of blood products;Rising quantity of hemoglobin;Neutrophils absolute value;Platelet count;Recovery time of blood count;Proliferation activity of sternum and iliac bone marrow;The number of megakaryocyte of sternum and iliac bone marrow;Anti-body of bone marrow cell membrane; | — |
Countries
China
Contacts
Public ContactZonghong Shao
General Hospital of Tianjin Medical University
Outcome results
None listed