perioperative hyperglycemia
Conditions
Interventions
control group:20 ml normalsaline
low dose of ulinastatin group:5 000U/kg ulinastatin
high dose of ulinastatin group:10 000U/kg ulinastatin
Sponsors
Department of Anesthesiology, Guangdong General Hospital
Eligibility
Sex/Gender
All
Age
33 Years to 71 Years
Inclusion criteria
Inclusion criteria: 1. patients scheduled for laparotomy hepatectomy; 2. Patients of ASA I-II; 3. Signed and dated written informed consent obtained from the subject and/or subject's legally acceptable representative prior to study participation.
Exclusion criteria
Exclusion criteria: Patients with abnormal electrocardiogram or chest X-ray, cardiac or pulmonary insufficiency, abnormal renal or hepatic function (Child-Pugh score higher than or equal to 10), preoperative hemoglobin less than 100g/l, allergic history, history of drug abuse and infusion liquid contain glucose within 6 hours before operation were excluded. Patients who had severe complications such as cardiovascular events, allergic shock, intraperitoneal hemorrhage, hepatic failure or application of insulin after operation were also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fasting plasma glucose; | — |
Secondary
| Measure | Time frame |
|---|---|
| cortisol;insulin;glucagon;interleukin-6;tumor necrosis factor-a;insulin sensitivity index; | — |
Countries
China
Contacts
Public ContactGuodong Zhao
Department of Anesthesiology, Guangdong General Hospital
Outcome results
None listed