Breast cancer
Conditions
Interventions
Treatment group:Partial-breast irradiation
Control group:Whole-breast irradiation
Sponsors
Gansu Cancer Hospital
Eligibility
Sex/Gender
Female
Age
45 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 35 to 70 years, the patient's ECOG performance status is 0 to 2, or KPS score is more than 70; 2. The patient's life expectancy is greater than five years,the other diease should consider 3. 0 (DCIS),I, II (size==4.0*10^9/L, absolute neutrophil count>=2.0*10^9/L, platelet count>=100*10^9/L, hemoglobin count=100g/L; 12. The patient is capable of understanding and complying with the protocol and has signed the informed consent document.
Exclusion criteria
Exclusion criteria: 1. Male breast cancer; 2. III, IV(size>=3?)stage breast cancer; 3. Suspected patients is not confirm by pathology; 4. Non epithelial malignant tumors, for example, sarcoma or lymphoma; 5. Multicenter tumor in more than one quadrant in breast or single lesion is more than 4?; 6. Bilateral breast cancer; 7. Patients with a history of breast cancer; 8. The surgery is not negative of surgical margin; 9. The operation cavity of patient is not clearly visible; 10. The patient has prosthesis implantation in breast; 11. The patient has radiation therapy at the tumor region; 12. The patient has a serious concomitant medical condition including collagen vascular disease, idiopathic dermatomyositis, active cutaneous lupus, scleroderma, systemic lupus erythematosus; 13. Patient is pregnant or nursing woman; 14. Patient is mental disease,nervous system diseases and did not describe the treatment effect 15. The patient has participated in clinical studies of non-approved experimental agents or procedures within 4 weeks; 16. The patient is unwilling to comply with study procedures, as specified by this protocol, or is unwilling to cooperate fully with the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Breast cancer recurrence;Local control rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival;recurrence free survival;distant metastasis free survival;quality of life;Boood routine test;Liver function test;renal function test;electrolyte test; | — |
Countries
China
Contacts
Public ContactXiaohu Wang
Gansu Cancer Hospital
Outcome results
None listed