Iodine deficiency, iron deficiency and subclinical thyroid deficiency
Conditions
Interventions
A: interventional group of mild ID in pregnancy :iodine supplement
B: control group of mild ID in pregnancy :None
C: control group with adequate iodine in pregnancy :None
D:interventional group of mild ID before pregnancy :iodine supplement
E:control group of mild ID before pregnancy :None
F:control group of adequate iodine before pregnancy:None
G:control women of TPOAb+ in pregnancy:None
H:treatment group of TPOAb+ pregnant women:levothyroxine
I:control women of TPOAb+ before pregnancy:None
J:treatment group of TPOAb+ women before pregnanc:levothyroxine
K:control group of hypothyroxinemia in pregnancy:None
L:treatment group of hypothyroxinemia in pregnancy:levothyroxine
M:control group of hypothyroxinemia before pregnancy :None
Sponsors
1st affiliated hospital of China medical university
Eligibility
Sex/Gender
Female
Age
22 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Pregnant women before the 8th gestational weeks (or women planning pregnancy); 2. Living in the region more than 5 years; 3. Singleton pregnancies (not including miscarriage); 4. No personal history and family history of known genetic diseases; 5. No personal history of severe chronic diseases 6 No smoking history; 6. Including the women intaking iodine or iron (or vitamine including iodine and iron).
Exclusion criteria
Exclusion criteria: 1. Women having chronic renal failure (serum creatinine> 133µmol/L), abnormal liver function (ALT > 1.5 times of upper limit of normal range), hypercalcemia (serum calcium > 2.75mmol/L), or hyperphosphatemia (serum phosphate > 1.46mmol/L) with renal rickets patients; 2. Women with untreated adrenal insufficiency, pituitary insufficiency and thyrotoxicosis; 3. Women with acute myocardial infarction, acute myocarditis and acute pancarditis; 4. Women with untreated coronary artery disease, angina, high blood pressure, arrythmia; 5. Women with gastrointestinal disease and allergies; 6. Women with artificial tocolysis and artificial fertilization.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| thyrotropin;Free thyroxine;Thyroid peroxidase antibody;Urine iodine content;Urine creatine;Pregnant and obstetrical complications;Delivery condition;Neonatal quality;Birth defect of the offspring;neurodevelopmental index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Iodine of hair or nail;Ferritin; | — |
Countries
China
Contacts
Public ContactWeiping Teng
1st affiliated hospital of China medical university
Outcome results
None listed