ST-elevated Acute Myocardial Infarction
Conditions
Interventions
high dose:80mg before PCI. then 40mg/d for 1 week. 20mg/d for one year
normol dose:20mg/d after PCI for 1 year.
Sponsors
Shanghai Ruijin Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The patients or entrust signed a informed consent; 2. Patients aged 18 ~ 80 years old; 3. Clinically diagnosised as STEAMI patients; 4. Patients those who received primary PCI <=12h sience the onset of chest pain; 5. The patients are willing to receive sirolimus eluting stent implantation; 6. The patients are willing and be able to accept the provisions of the interview, treatment, laboratory tests and other research activities.
Exclusion criteria
Exclusion criteria: 1. Patients with stable angina pectoris (SAP), unstable angina or non ST segment elevation myocardial infarction (NSTEMI) patients; 2. Patients allegy to tolerate atorvastatin / other statins, or prior to atorvastatin / other statins; 3. Patients allegy to aspirin, clopidogrel, heparin, on stainless steel, contrast agent or zotarolimus; 4. Patients do not aggre to receive coronary angiography and clinical follow-up; 5. Patients already has liver dysfunction: ALT >=3ULN (3 times above the normal high limit); 6. Patients with dignosised liver disease (such as cirrhosis, chronic hepatitis B e antigen positive etc.) or muscle disease (such as myopathy, muscular dystrophy,); 7. Patients with severe renal insufficiency: serum creatinine or creatinine clearance rate of 3mg/dl; 8. Patients with severe left ventricular dysfunction: Killip >=3 grade classification; 9. Patints who are taking drugs interact with atorvastat, such as fibric acid derivatives, cyclosporin, macrolide antibiotics, protease inhibitors, azoles antifungal drugs, niacin, ezetimibe, Vera Pammy etc.; 10. Alcohol or drug abuse history in the past 12 months; 11. Wonen who are currently pregnant, lactating or fails to take effective contraceptive measures for women of childbearing age; 12. Patients also participate in other research; 13. Patients who can not understand the study protcol, or not / is not willing to follow the research program; 14. The prior PCI or coronary surgical operation treatment; 15. Patients' life expectancy is less than 12 months; 16. The presence of other serious adverse disease or abnormal laboratory results, the researchers estimate the patients not involved in the study.
Countries
China
Contacts
Public ContactRuiyan ZHANG
Shanghai Ruijin Hospital
Outcome results
None listed