Anti-epilepsy drugs prophylaxis in cranioplasty for patients with skull defection: A prospective randomized controlled study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-13003743

Enrollment

Unknown

Registered

2013-10-12

Start date

2014-02-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy

Interventions

Two groups:levetiracetam prophylaxis vs without levetiracetam prophylaxis

Eligibility

Sex/Gender

All

Age

16 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Subjects with 16-60 years old; 2. Subjects without seizure history before cranioplasty; 3. Subjects had no neurosurgical operation but the decompressive cranioectomy before cranioplasty; 4. Subjects whose score of Kamofsky Scale >=70; 5. Subjects with single skull defection; 6. Subjects who underwent cranioplasty with titanium meshes; 7. Subjects who are able to follow the investigational study procedures and who/whose family members are willing to give written consent for the study.

Exclusion criteria

Exclusion criteria: 1. Subjects with hydrocephalus who underwent vertriculperitoneal shunt at the same time with cranioplasty; 2. Subjects present intracranial hematoma or infection after cranioplasty; 3. Subjects with family epilepsy history.

Countries

China

Contacts

Public ContactShuli Liang

The First Affiliated Hospital of PLA General Hospital

liangsl_304@sina.com+86 13439390206

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026