atrial fibrillation/atrial flutter
Conditions
Sponsors
Qilu Hospital, Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. older than 18; 2. intracardiac thrombus, mainly in left atrial appendage detected by Echocardiography; 3. ECG or Holter based atrial fibrillation/atrial flutter; 4. Echocardiography shows hemodynamic stable non-valvular atrial fibrillation or atrial flutter;
Exclusion criteria
Exclusion criteria: 1. Hypersensitivity to the active substance or to any of the excipients; 2. Patients with severe renal impairment (CrCL less than 30 mL/min); 3. Active clinically significant bleeding; 4. Lesion or condition, if considered a significant risk factor for major bleeding. This may include current or recent gastrointestinal ulceration, presence of malignant neoplasms at high risk of bleeding, recent brain or spinal injury, recent brain, spinal or ophthalmic surgery, recent intracranial haemorrhage, known or suspected oesophageal varices, arteriovenous malformations, vascular aneurysms or major intraspinal or intracerebral vascular abnormalities; 5. Concomitant treatment with any other anticoagulants e.g. unfractionated heparin (UFH), low molecular weight heparins (enoxaparin, dalteparin etc), heparin derivatives (fondaparinux etc), oral anticoagulants (warfarin, rivaroxaban, apixaban etc) except under the circumstances of switching therapy to or from Pradaxa or when UFH is given at doses necessaryto maintain an open central venous or arterial catheter; 6. Hepatic impairment or liver disease expected to have any impact on survival; 7. Concomitant treatment with systemic ketoconazole, cyclosporine, itraconazole, tacrolimus and dronedarone; 8. mechanical heart valves requiring anticoagulant treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| coagulation indicator;Echocardiography;blood routine examination; | — |
Countries
China
Contacts
Public ContactJingquan Zhong
Qilu Hospital, Shandong University
Outcome results
None listed