chronic kidney disease
Conditions
Interventions
Jianpiqinghua formula & telmisartan placebo:Jianpiqinghua formula & telmisartan placebo
Telmisartan & jianpiqinghua formula placebo:Telmisartan & jianpiqinghua formula placebo
Jianpiqinghua formula & telmisartan:Telmisartan & jianpiqinghua formula
Sponsors
Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Male
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years; 2. To be diagnosed as original chronic renal glomerular disease at CKD III stage, more than 70% were confirmed by histopathological examination of renal puncture; 3. 24h urinary protein excretion 0.5-2.0 grams; 4. At the begining and end of 2 weeks introducing period, GFR will be 30~59ml/min/1.73m2, 24h urinary protein excretion 0.5-2.0 grams, Bp=130/80 mmHg; 5. Has to be treated with two weeks wash-out duration for those patients used angiotensin converting enzyme inhibitors (ACEI)/angiotensin II receptor antagonist (ARB) therapy; or those not used ACEI/ARB previously; 6. Non-dialysis patients whose risk factors such as infection, acidosis, electrolyte disorder, and hypertension, etc., have been controlled and with stable status, blood pressure 130-90/80-60mmHg and blood K+ concentration falls in normal range; 7. To be with TCM "spleen deficiency and damp-hot (Pixu Shire)" symptoms (zheng); 8. Accecpt protocol and signed informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1. Complicated with severe heart, brain, liver and blood system diseases; 2. Pregnancy or lactation period woman; 3. Patient with allergy reaction against the trial drug; 4. Patient is/was currently or in past three months involved in other clinical trial, or used glucocorticoids, immunosuppressants, Tripterygium preparations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24h urinary protein excretion;urinary MA/Cr;serum creatitine;eGFR;blood urea nitrogen;serum albumin; | — |
Countries
China
Contacts
Public ContactLiqun He
Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed