HBV
Conditions
Interventions
PEG-IFN a-2a group:PEG-IFN a-2a for 48 weeks (with ETV overlapped in
ETV group:PEG-IFN a-2a for 48 weeks (with ETV overlapped in
Sponsors
Guangdong General hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Adult patients (18-65 years of age); Received ETV for at least 96 weeks; HBV DNA <500 copies/mL, HBeAg <=100 PEIU/mL and HBsAg<=1000IU/mL; The urine or blood pregnancy test was negative 24 hours before using drug; Patients without cirrhosis on liver biopsy (choice); Willing to accept treatment and Signe informed consent form
Exclusion criteria
Exclusion criteria: Women who are pregnant or breast-feeding; Combined with HAV, HCV, HDV or HIV infection; Decompensated liver disease (Child-Pugh more than five points); Neutrophil count 1.5 ULN; Alcohol and/or drug abuse within half a year of entry; History of severe psychiatric disease or immunologically mediated disease; Bleeding from esophageal varices or other conditions consistent with decompensated liver disease; Severe cardiac or chronic pulmonary disease; Severe seizure disorder or current anticonvulsant use; Active or suspected cancer; History of antineoplastic or immunomodulatory treatment including systemic corticosteroids; Major organ transplantation; thyroid disease; Severe retinopathy and a history of other severe illnesses or conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBeAg seroconversion; | — |
Secondary
| Measure | Time frame |
|---|---|
| HBeAg loss;HBsAg loss;HBsAg loss;HBsAg seroconversion; | — |
Countries
China
Contacts
Public ContactChen Xiaoping
Guangdong General Hospital
Outcome results
None listed