Radix Astragali and Plastrum testudinis induce synthesis of fetal hemoglobin in ß-thalassemia

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-13003727

Enrollment

Unknown

Registered

2013-10-21

Start date

2013-10-24

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ß-thalassemia

Interventions

treatment group:Radix Astragali and Plastrum testudinis dosage was 10 g/day each for patients aged 1-3 years, 15 g/day each for patients aged 4-6 years, 20 g/day each for patients aged 7-11 years,or 3

Placebo group:placebo dosage was 20 g/day for patients aged 1-3 years, 30 g/day for patients aged 4-6 years, 40 g/day for patients aged 7-11 years,or 60 g/day for patients 12-18 years.

Eligibility

Sex/Gender

All

Age

1 Years to 20 Years

Inclusion criteria

Inclusion criteria: 1. To be diagnosed as ß-thalassemia; 2. start transfusion after 2 years old; 3. no or occasionally blood transfusions(1 or 2 times per year)and maintain Hb >=7g/dl; 4. no blood transfusions for at least 3 months.

Exclusion criteria

Exclusion criteria: 1. transfusion-dependent; 2. immunodeficiency; 3. poor renal or hepatic function; 4. current antianemic therapy; 5. poor treatment compliance, or 6. no regular visits for blood tests.

Design outcomes

Primary

Measure	Time frame
blood routine test;Hb;ferritin;iron metabolism indexs;hepatic and renal functions;	—

Secondary

Measure	Time frame
reticulocyt;	—

Countries

China

Contacts

Public ContactXinhua Qian

Department of Neonatology, Nanfang Hospital

qxh_nfyy@163.com+86 020-62787340

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026