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Study on Monitoring the Effect of Chewing Sugarless Gum on Remineralization of Early Caries via Quantitative Light-induced Fluorescence (QLF)

Study on Monitoring the Effect of Chewing Sugarless Gum on Remineralization of Early Caries via Quantitative Light-induced Fluorescence (QLF)

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-TRC-13003711
Enrollment
Unknown
Registered
2013-10-20
Start date
2012-02-20
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Early Caries

Interventions

A:chewing 2 pieces of Wrigley’s Chewing Gum for test for one time, 12min/time, 5 times/day (equal to 10 pieces)
B:chewing 2 pieces of Wrigley’s Chewing Gum for test for one time, 20 min/time, 3 times/day (equal to 6 pieces)

Sponsors

Sichuan University, West China Hospital of Stomatology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
8 Years to 13 Years

Inclusion criteria

Inclusion criteria: Of all maxillary anterior teeth, there shall be at lest 1-2 early caries on smooth surfaces (demineralized but not cavitated, according to Nyvad et al, 1999). Subjects shall be in sound physical conditions without systemic diseases. Subjects, aged between 8 and 13, shall have at least 4 maxillary anterior teeth (3-3). Subjects can take a 16-week clinic study. Subjects can understand test requirements, and agree to chew gums and use toothpastes and toothbrushes provided.

Exclusion criteria

Exclusion criteria: Those using fluoride mouthrinse; taking medicine in long term due to chronic diseases; wearing fixed orthodontic appliances; having severe congenital maxillofacial malformations; having taken other clinic studies during last 2 months; having primary teeth, permanent teeth not fully erupted, fixed artificial teeth, dental fluorosis that can be seen by naked eye, tetracycline stained teeth, or enamel hypoplasia; or allergic to gum substances or using gums.

Design outcomes

Primary

MeasureTime frame
?F (the loss of fluorescence), Area (the area of lesions), and ?Q (the total loss of fluorescence) o;

Secondary

MeasureTime frame
Caries examination;

Contacts

Public ContactHu Deyu

West China School of Stomatology, Sichuan University

hudeyu@vip.sina.com+86 13908034990

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026