IgA Nephropathy
Conditions
Interventions
Experimental Group:Chinese Herb Prescription Granule, 6g, Bid, po. 48 weeks
Placebo Comparator:Placebo of Chinese Herb Prescription Granule, 6g, Bid, po. 48 weeks plus prednisone, 0.5mg-1mg/kg/d, po. 48 weeks
Sponsors
Department of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Confirmed by renal biopsy and clinical examination as primary IgA nephropathy; 2. Pathology:upon Lee's grade III; 3. Aged 18-60 years old; 4. Gender and nationality are not limited; 5. Chronic Kidney Disease(CKD) Stage 3: (59 ml/min>GFR>30ml/min/1.73m2); 6. 24-hour urine protein >=1.0g. Informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients within the past 3 months had received immunosuppressive agents or cytotoxic therapy is greater than 4 weeks; 2. Patients within the past 3 months who have received corticosteroids (prednisone or prednisolone) dose of more than 20mg / d up to 4 weeks; 3. Patients suffering from acute or rapidly progressive glomerulonephritis; 4. Patients continue with active hepatitis B and abnormal liver function tests transaminase; 5. Patients with a history of malignant tumor or malignancy, HIV infection, history of mental illness, acute central nervous system disorders, severe gastrointestinal disease, prohibiting the use of immunosuppressive agents; 6. Abnormal glucose metabolism, fasting blood glucose more than 6.2mmol/L; 7. Pregnancy or breast-feeding women; 8. Receiving other clinical trials; 9. Associated with other serious diseases and organ dysfunction; 10. Combined life-threatening complications such as severe infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glomerular filtration rate;24 hours urine protein; | — |
Countries
China
Contacts
Public ContactYueyi Deng
Outcome results
None listed