chronic obstructive pulmonary disease
Conditions
Interventions
variable dose:Variable Dose Corticosteroid
Conventional Fixed Dose:40 mg intravenous prednisone
Sponsors
Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China.
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: All patients who were 40-80 years old with known COPD and who were hospitalized because of an exacerbation and were eligible for entry into the study. Exacerbation of COPD was defined as the presence of 2 or more of the following: worsening dyspnea,increase in sputum purulence, or increase in sputum volume.
Exclusion criteria
Exclusion criteria: Patients were excluded if they had a history of (1) asthma; (2) use of systemic corticosteroids within the preceding month; (3) use of systemic corticosteroids for the treatment of COPD exacerbation for more than 24 hours at the time of randomization; (4) clinical or radiologic evidence of pneumonia; (5) uncontrolled left ventricular failure requiring the use of inotropes or vasoactive drugs; (6) uncontrolled arterial hypertension; (7) uncontrolled diabetes mellitus; (8) a neuromuscular disease; or (9) allergy and or adverse reaction to corticosteroid therapy;(10)Admitted directly to RICU;(11) pH 9.3 kPa(70mmHg)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A composite measure of treatment failure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of stay and hospital costs; | — |
Countries
China
Contacts
Public ContactGuoqiang Cao
Outcome results
None listed