Stable angina pectoris
Conditions
Interventions
Yi Qi Jian Pi and Qu Tan Hua Zhuo:Integrative treatment program with granular formulation Yi Qi Jian Pi and Qu Tan Hua Zhuo
Yi Qi Jian Pi and Qu Tan Hua Yu:Integrative treatment program with granular formulation Yi Qi Jian Pi and Qu Tan Hua Yu
Sponsors
Liaoning University of TCM
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnosis criteria of coronary heart disease whth stable angina pectoris as well as spleen deficiency and phlegm syndrome; (2) Age: Male: 45-75 years old (included 45 and 75 years old), Female: 50-75 years old (included 50 and 75 years old); (3) Informed consent and voluntarily take part in this trail,signed consent form; (4) Coronary angiog raphy or coronary CT founded coronary stenosis between 50% and 75%(examination report should be offered) within 3 months,or coronary CT founded coronary stenosis between 50% and 75% before into the group.
Exclusion criteria
Exclusion criteria: (1) Except spleen deficiency and phlegm syndrome; (2) Patients with chest pain from the unstable angina pectoris and hypertrophic cardiomyopathy and other heart diseases,neurosis,climacteric syndrome and cervical spondylosis,Gastric and esophageal reflux and so on; (3) Coronary angiog raphy or Coronary CT founded that trunk blood vessel(RCA,LM,LAD,LCX) more than 75% stenosis; (4) Patients with acute myocardial infarction in the second half of this year or complete revascularization history within a year; (5) Patients with severe heart failure(heart function class IV),severe arrhythmia,hypertension was higher than that of 160/100mmHg after standard antihypertensive therapy, severe other system diseases (eg.malignant tumor, gastrointestinal hemorrhage,gastric ulcer and) that may not able to finish the trial and the function of liver and kidney was abnormal (blood AST, ALT, Cr cap of 1.5 times more than a reference value); (6) severe dementia; (7) Pregnancy and planned pregnancy or breast-feeding women; (8) Patients with the Chinese medicine granule and allergy to iodine; (9) Patients with glaucoma; (10) Patients took part in other clinical researches in the past two months; (11) No consent form signed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The frequency of angina pectoris attack;The dosage of nitroglycerin;Body limited dimensions of SAQ integral;Except for the limited dimension integral body SAQ;TCM syndrome;The duration of angina pectoris;Angina pain severity;Blood serum metabonomics;TC;TG;LDL;HDL;ox-LDL;MicroRNA33;HMG-COA;adherence factor PS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Scavenger receptor A;Scavenger receptor B;Chemokine MCP-1;adherence factor VCAM-1;hypersensitive c reactive protein;Blood homocysteine;Glucagon like peptide -1;angiotonin ?;5-HT;VIP;NE;Ach;Ghrelin;mtDNA copy number;MicroRNA 126;MicroRNA155;MicroRNA 125;MicroRNA 221;MicroRNA 222; | — |
Countries
China
Contacts
Public ContactYang Guanlin
Affiliated hospital of Liaoning University of TCM
Outcome results
None listed