chronic heart failure
Conditions
Interventions
treatment group:Routine conventional medicine + Traditional Chinese medicine
control group:Routine conventional medicine
Sponsors
Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. The basic primary heart disease is CHD ( with diagnosis for CHD: confirmed by coronary angiography; confirmed by coronary CT; history of acute myocardial infarction; limb-salvage Q wave for ECG; ecg ECG test and radionuclide examination support, etc.); No history of hypertension or taking antihypertensive drugs, with blood pressure under 160/100 mmHg; 2. With a history of CHD, symptoms and signs; with difficult breathing, fatigue and fluid retention (edema); with left ventricular enlargement, end systolic volume of left ventricular increase and LVEF <=50%; with NYHA functional classifiction II or III; 3. Male or female subjects between 40 and 75 years old; 4. All subjects provided witnessed written consentand they voluntarily participate in the investigation.
Exclusion criteria
Exclusion criteria: 1. Combine with serious valvular heart disease, pericardial disease, cardiomyopathy, congenital heart disease, AMI ( within 4 weeks), cardiac shock, acute myocarditis or serious arrhythmia with the variation of hemodynamics; 2. Combine with pulmonary artery hypertension caused by cor pulmonale, acute or chronic pulmonary embolism, or stroke within a half year; 3. Combine with serious hepatic insufficiency ( the index of liver function being 2 times of normal one), renal insufficiency (Ccr>20%, Scr>3mg/dl or 265 µmol/L), diseases of blood system, malignant tumor, diabetes mellitus with serious complications, hyperthyrea or hypothyrea; 4. Combine with infection: fever; the numeration of leukocyte being more than 10×109/L, the percentage of neutrophile granulocyte being more than 85%; patchy shadows in X ray of Chest, meeting one of the above three; 5. Pregnancy or lactation; mental disease and infectious disease patients; 6. Take part in other trials within two months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular ejection fraction (LVEF); | — |
Secondary
| Measure | Time frame |
|---|---|
| 6-minute walk test (6MWT);TCM syndrome scores (TCM-SS);New York Heart Association functional classification;Cost-effectiveness analysis; | — |
Countries
China
Contacts
Public ContactWei Wang
Outcome results
None listed