cervical carcinoma
Conditions
Interventions
lidocaine group and normal saline group:Patients scheduled to receive lidocaine (lido group) were given an intravenous bolus injection of 1.5 mg/kg of lidocaine in 10 min (30 min before surgical incis
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
Female
Age
25 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. patients suffered from cervical carcinoma and scheduled for elective colorectal surgery; 2. American Society of Anesthesiologists physical status I to III; 3. Aged between 18 to 75 years; 4. body weight betwween 45-65kg; 5. obtaining written informed consent.
Exclusion criteria
Exclusion criteria: known allergies to local anesthetics, chronic use of analgesics or corticosteroids, underlying inflammatory bowel disease (Crohn's disease or ulcerative colitis), prolonged postoperative ventilatory support, impaired liver function, severe cardiac arrhythmia,and mental disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the level of high mobility group protein box1 expression;test the concentration of lidocaine in plasma; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative VAS pain scores;Times to first flatus, defecation;postoperative fatigue scores;postoperative nausea and vomiting;the level of high mobility group protein box1 expression;lymphocytes apoptosis was tested by TUNEL;IL-1ra;IL-6; | — |
Countries
China
Contacts
Public ContactHuan-Liang Wang
Qilu Hospital of Shandong University
Outcome results
None listed