diabetic kidney disease
Conditions
Interventions
treatment group:conventional treatment of western medicine plus tangshenfang
placebo group:conventional treatment of western medicine plus placebo
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) DKD diagnostic criteria;a) type 2 diabetes;b) Diabetic retinopathy; (2) 24h urinary protein (24-h UP) level between 0.5 and 3.5 gram; (3) serum creatinine <265umol/L(3mg/dl); (4) with hypertension (blood pressure can be controlled <=130 / 80mmHg by anti-hypertension agents) or without hypertension; (5) HbA1c <=7.5%; (6) Chinese syndrome differentiation type as Qi and Yin deficiency and blood stasis; (7) Taking Irbesartan continuously for 2 weeks, 300mg daily; (8) aged between 18 and 70 years old; (9) signed informed consent.
Exclusion criteria
Exclusion criteria: (1) blood pressure 5.5mmol/L or <3.5mmol/L; (3) doubling of serum creatinine within half a year; (4) renal artery stenosis; (5) other server diabetic complications or serious macrovascular events within half a year. For example, cerebral hemorrhage, massive cerebral infarction and Acute myocardial infarction; (6) recent infection within 4 weeks; (7) other primary or secondary renal disease; (8) other server diseases, malignant tumor; (9) server mental disorders; (10) pregnant or lactating women; (11) allergic to component of agents in this study; (12) Involved in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24 hours urinary protein;high-sensitivity C-reactive protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum creatinine;estimated glomerular filtration rate;traditional Chines medicine scores;triglyceride;total cholesterol;low density lipoprotein;high-density lipoprotein; | — |
Countries
China
Contacts
Public ContactPing Li
China-Japan Friendship Hospital
Outcome results
None listed