locally advanced esophageal squamous carcinoma
Conditions
Interventions
2:involved field radiotherapy combined with concurrent S-1 and cisplatin chemotherapy
1:selective lymph nodes radiotherapy
Sponsors
Shandong Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) demonstrated pathology as stage II to IVA esophageal squamous cell carcinoma; 2) ECOG scores are 0 - 1 and life expectancy >6 months; 3) age range from 18 to 75 years old; 4) without chemotherapy before inclusion; 5) not received radiotherapy; 6) not received operation treatment; 7) without severe complications; 8) Blood and liver and kidney function: Neutrophil count >=1500/mm3 Blood platelet >=100,000/mm3; Hemoglobin>=100g/l; Transaminase<=2.5 times of the upper limit of normal values; Bilirubin <=1.5 times of the upper limit of normal values; AKP<=5 times of the upper limit of normal values; CR <=1.5mg/dl; 9) Signed informed consent.
Exclusion criteria
Exclusion criteria: 1) with other malignant tumor; 2) pregnant or lactating patients; 3) fertility but did not use contraception; 4) serious complications; 5) in other clinical trials now or four weeks before; 6) use other anti-cancer drugs at the same time; 7) had organ transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Local- Regional failure free survial, LRFF; | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival;progression free survival;local control;regional control;short-term efficacy;side effects;treatment compliance ; | — |
Countries
China
Contacts
Public ContactBaosheng Li
Shandong Cancer Hospital
Outcome results
None listed