Graves' disease (Hyperthyroidism)
Conditions
Interventions
A:lithium carbonate
B:methimazole
C:lithium carbonate combination with methimazole
Sponsors
Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. volunteered to participate and signed informed consent; 2. aged 18-65yrs; 3. newly diagnosed Graves' disease; 4. strictly followed the project requirement during the trail.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or lactation period; 2. With history of: liver disease (except fatty liver) such as liver cirrhosis, HBV and HCV (except carrier), or ALT, AST or TBil above 2 folds of normal upper limit; renal disease or clinically diagnosed renal insufficiency, male SCr >=132umol/L, female SCr >=123umol/L; congestive heart failure need medicine treatment; torsade de pointes, ventricular tachycardia or fibrillation, second or third degree A-V block, or prolonging QTc (>500ms); myocardial infarction within 6 months, undergone coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI), unstable angina pectoris or apoplexy;leukopenia,<3.0×10^9/L, or neutropenia, <1.5×10^9; 3. Organic brain disorder, severe physical disease, or hyponatremia; 4. Potentially unreliable patients, or not suitable for the trial considered by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TT4;TT3;FT4;FT3;TSH;TRAb;High metabolic syndrome;Goiter;Radioactive iodine uptake; | — |
Secondary
| Measure | Time frame |
|---|---|
| Body weight;TPOAb;TgAb;ECG;Blood routine; | — |
Countries
China
Contacts
Public ContactLiu Chao
Outcome results
None listed