Poor ovarian responders
Conditions
Interventions
Experimental group:mild ovarian stimulation
Control:Controlled ovarian stimulation
Sponsors
Sixth affiliated Hospital of Sun Yet-san University
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Poor ovarian responders are recruited in this study. POR is defined according to the Bologna criteria, published in 2011. To define POR, at least two of these three following features must be presented: 1. Advanced maternal age (=40 years) or any other risk factors for POR (including pelvic infection, ovarian endometriomas, history of ovarian surgery, history of chemotherapy, especially with alkylating agents); 2. A previous POR (<=3 oocytes with a conventional controlled ovarian stimulation); 3. An abnormal ovarian reserve test, i.e. basal AFC <=6; 4. Besides, the inclusion criteria also included: A normal BMI (18-25 Kg/m2); A regular menstruation (with cycle 23-35 days).
Exclusion criteria
Exclusion criteria: 1. Whith history of repeated IVF failure (previous IVF cycle >2); 2. Severe Adenomyosis; 3. Abnormal uterine cavity, such as intrauterine adhesions; 4. PCOS patients; 5. History of allergic to ovulation induction medicines; 6. Attending other clinical trials in the same period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate;Ongoing pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| implantation rate;live birth rate;Spontaneous miscarriage rate;Serum FSH level;Serum E2 level;Hormal level in follicular fluid; | — |
Countries
China
Contacts
Public ContactHuang Rui
Outcome results
None listed