Acute fever in children
Conditions
Interventions
A group (experimental group):alternating acetaminophen and ibuprofen
B group (control group 1):acetaminophen monotherapy
C group (control group 2):ibuprofen monotherapy
Sponsors
Department of Paediatrics, West China Second University Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
No minimum to 5 Years
Inclusion criteria
Inclusion criteria: Febrile children aged 6 months to 5 years will be eligible if their anxillary temperature are equal to or greater than 38.5? and their history of fever are less than 3 days.
Exclusion criteria
Exclusion criteria: Children will be excluded if they have any of the following conditions: mild or more severer dehydration, known allergy or contraindication to any antipyretic, any acute or chronic hepatic disease, all acute or chronic renal disease with the exception of urinary tract infection, known coagulation abnormalities or active bleeding disorders, blood system diseases, malignancy, digestive ulcer, asthma or bronchiolitis, chronic metabolic disease, immune system diseases and require hormone therapy, any neurological or skin disease that may affect central thermoregulation, hypertension, critical ill condition, any medical or surgical condition that preclude take or absorb antipyretic (such as frequent vomiting), a history of any antipyretic or medicine with antipyretic effect use in the preceding 8 hours, require to take medicine which affect temperature (such as Topiramate). Children will also be excluded if they have taken part in this trial one time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Non-communicating Children’s Pain Checklist – Revised (NCCPC-R) score;axillary temperature; | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of persistent fever;incidence of poor antipyretic effect;times of antipyretic use;incidence of low body temperature;incidence of rash for all causes;incidence of asthma for all causes;incidence of gastrointestinal symptoms for all cause ;incidence of hepatic dysfunction for all causes;incidence of renal dysfunction for all cause; | — |
Countries
China
Contacts
Public ContactWan Chaomin
Outcome results
None listed