Breast cancer
Conditions
Interventions
targeted group:3ml carbon nanoparticles-epirubici suspension was injected into 4 points around the areola before operation
tracer group:1ml carbon nanoparticles suspension was injected into 4 points around the areola before operation
Control group:Modified radical mastectomy of breast cancer
Sponsors
Southwest Hospital, Third Military Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Female aged 18-70 years; 2. The diagnosis of invasive breast cancer has been confirmed by preoperative core needle biopsy; 3. Has enlarged axillary lymph nodes on preoperative examination, no axillary operation history; 4. Without distant metastasis; 5. No chest wall and breast radiotherapy history; 6. Non pregnant and lactating breast cancer; 7. Heartlungliver and kidney shoud no obvious abnormalities, no coagulation dysfunction and other operation contraindication; 8. No other malignancy; 9. Be able to follow the scheme, the patients agree to participate in the trials and sign the informed consent and date.
Exclusion criteria
Exclusion criteria: 1. Tumor distant metastasis; 2. Had axillary operation history; 3. Pregnant or lactating female patients; 4. Complicated serious disease (such as: heart exclus diseaseliver diseasekidney disease,etc) for exsist less than 2 years by estimate; 5. Patients who are not convenient to go to the doctors' office for recheck for any reason; 6. Have a particular allergy to Carbon nanoparticles or epirubicin; 7. The researchers believe that the patients are not suitable for this clinical trial for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1, 3, 5 years relapse/ metastasize Rate; survival rate; overall survival rate;Determination of drug concentration in axillary lymph nodes; | — |
Countries
China
Contacts
Public ContactLinjun FAN
Outcome results
None listed