ischemic stroke
Conditions
Interventions
Two groups:transcranial magnetic stimulation & robotic-hand therapy 10 sessions for TBS, 20 sessions for robotic-hand therapy versus sham transcranial magnetic stimulation
Sponsors
Division of Neurology, Department of Medicine & Therapeutics, The Chinese University of Hong Kong
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) patients aged 18 or above; 2) first-ever ischemic subcortical stroke with onset time less than 21 days; 3) hand weakness as a result of stroke; 4) intracerebral hemorrhage excluded by brain computed tomography (CT) / magnetic resonance imaging (MRI); 5) the patient or his/her legally acceptable representative is willing to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1) personal history of epilepsy; 2) metallic implants in any part of body; 3) implanted cardiac pacemaker, defibrillator, medication pump or any other implanted electronics; 4) severe skull fracture, serious head injury, history of brain or spinal cord surgery; 5) brain tumour or other significant non-ischemic brain lesion on CT/MRI; 6) administration of drugs that potentially lower seizure threshold; 7) severe hand spasticity, open hand wound or hand deformity; 8) history of malignancy; 9) severe co-existing systemic diseases, severe dementia or psychosis; 10) inability to be followed up at regular interval; 11) pregnancy or breast-feeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Upper limb fugl-meyer assessment (FMA); | — |
Secondary
| Measure | Time frame |
|---|---|
| RMT, AMT, MEP, S/R curve, Power Grip, Lateral Pinch Grip, Purdue Pegboard for both hands, NIHSS, mRS; | — |
Countries
China
Contacts
Public ContactKa Sing WONG
Division of Neurology, Dept of Medicine and Therapeutics, PWH
Outcome results
None listed