Nasopharyngeal Carcinoma
Conditions
Interventions
Experimental:Two circles induction chemotherapy (cisplatin and 5-fluorouraacil) with cisplatin 100 mg/m2(divided in 3 days)in 250 ml NS over 30 mins IV on and 5-fluorouraacil 1000 mg/m2/d in 5%GS cont
Active Comparator:Seven circles cisplatin 40 mg/m2 on Day 1 of every week and concurrent radiotherapy up to 70Gy
Sponsors
Tumor Center of Wuhan General Hospital of Guangzhou Military Command
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with newly histologically confirmed non-keratinizing carcinoma (according to World Health Organization (WHO) histologically type); 2. Tumor staged as N2-3 or T3-4N1 (according to 6th American Joint Committee on Cancer staging system); 3. No evidence of distant metastasis (M0); 4. Performance status: KPS >=70; 5. With normal liver function test (Alanine AminotransferaseAspartate Aminotransferase =60ml/min; 7. Adequate marrow: leucocyte count >=4000/uL, hemoglobin >=80g/L and platelet count >=100000/uL; 8. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. WHO Type keratinizing squamous cell carcinoma or basaloid squamous cell carcinoma; 2. Aged >=70 or <18; 3. With a history of renal disease; 4. Prior malignancy; 5. Previous chemotherapy or radiotherapy; 6. Patient is pregnant or lactating; 7. Unstable cardiac disease requiring treatment; 8. Emotion disturbance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response rate after the comprehensive treatment;Acute toxicity reaction; | — |
Secondary
| Measure | Time frame |
|---|---|
| 1-year locoregional failure-free survival;1-year distant failure-free survival;1-year overall survival; | — |
Contacts
Public ContactYi Feng-tao, Zhang Fan
Outcome results
None listed