Correlative study on control of cognitive dysfunction after coronary artery bypass grafting

Clinical study on ulinastatin and minocycline in control of cognitive dysfunction after coronary artery bypass grafting

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-13003349

Enrollment

Unknown

Registered

2013-05-25

Start date

2013-07-15

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary heart disease

Interventions

1:Minocycline

2:ulinastatin

3:dexmedetomidine

Eligibility

Sex/Gender

All

Age

45 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. aged >=60; 2. patients undergoing elective coronary artery bypass surgery; 3. NYHA I-III.

Exclusion criteria

Exclusion criteria: 1. march exclusion criteria of MMSE; 2. patients with central nervous system diseases or mental disease; 3. previous neurosurgery; 4. taking sedative drugs or antidepressants; 5. patients with severe visual obstacle or audio obstacle that can not finish evaluation in Scale of Cognitive function; 6. patients with ventricular aneurysm or LVEF<40%; 7. patients who need second thoracotomy for exploratory; 8. patients who refuse to take part in the study.

Design outcomes

Primary

Measure	Time frame
Cor;IL-1ß;IL-6;TNF-a;IL-10;CRP;neuron speeifie enolase (NSE);S100ß;	—

Countries

China

Contacts

Public ContactGe Yali

ge_yls@sina.com+86 13952091009

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026