binge drinking induced liver damage
Conditions
Interventions
Experimental group:drink alcohol
parallel control group:drink water
Sponsors
Southern Medical University
Eligibility
Sex/Gender
Male
Age
21 Years to 45 Years
Inclusion criteria
Inclusion criteria: Participants are 21-45 years adult male. Inclusion criteria:Body Weight is in the range of standard weight ± 10% [standard body weight (kg) = 0.7*(height cm-80)]; all tests of heart, liver, kidney, blood and others are in normal range; no history of alcohol dependence; ethanol consumption less than 140g per week over the last three months before the trial; no single-dose heavy drinking(defined as ethanol consumption more than 80g per day); no alcohol drinking during the last two weeks before the trial; no sickness or medication during the last one week before the trial; have already signed the informed consent of this project.
Exclusion criteria
Exclusion criteria: No drinking experience; who has already participated in other clinical trials in four weeks before the start of the project; Who has a allergy of alcohol food or other drugs; who has fainting history with the reason of low blood sugar or acupuncture syncope; who is easy to vomit after a little drinking(about 50ml liquor of 40 degrees); non-alcoholic fatty liver disease (fatty liver disease obese persons and spontaneous fatty liver); who is a mental or physical disability; who has a lower income group might nature (such as the infirm, etc.) based on investigator's judgment; gastrointestinal system diseases (such as acute and chronic gastritis, gastric ulcer and duodenal ulcer, etc.); cardiovascular disease (hypertension, hypotension, arrhythmia, atrial fibrillation, etc.); who has a history of liver diseases with viral infections (such as hepatitis B, hepatitis C); respiratory system diseases (eg, pneumonia, asthma).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The expression of caveolin-1 in serum;Liver function tests;blood lipid tests;Blood alcohol concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tempreture;Blood pressure;Heart rate; | — |
Countries
China
Contacts
Public ContactLYU Zhiping
Outcome results
None listed